制浆造纸酶学科研团队
1. 团队概述
制浆造纸酶学课题组创建于2018年，主要在生物质材料结构解析与酶作用机理、制浆造纸用酶的挖掘与开发、生物酶工业化应用技术的研究、工业微生物育种、农业废弃物高值化转化利用、微生物资源发掘及功能开发等方向开展研究，截止目前承担国家重点研发计划、国家自然科学基金、863计划、等省部级项目20余项，在国际主流刊物上发表SCI高水平论文90余篇,授权发明专利40余项，获国家科技进步二等奖、山东省技术发明一等奖、山东省科技进步一等奖等在内的省部级及以上科研奖励10余项。
团队现有在职教工8人，每年招收博士研究生约4-8人、硕士研究生约16-20人。
2.研究方向
(1)微生物酶的开发及应用技术研究
(2)生物智能制造装备
(3)食品安全危害物降解与消除
(4)生物催化与蛋白质工程
(5)工业微生物育种
(6)微生物代谢工程
(7)生物质精炼及高值化利用
(8)生物基产品研发及应用
(10)微生物资源发掘及功能开发
3.团队成员
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团队负责人 | 刘同军 教授 | 张杰 教授 | 肖静 教授 |
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刘开泉 副教授 | 谭丽萍 副教授 | 孙登岳 博士 | 李霞 博士 |
4.代表性研究成果
近年来承担并完成省部级及以上科研项目20余项，国家级和省部级奖励10余项,授权发明专利40余项，发表论文100余篇（SCI论文90余篇），具体如下：
4.1 省部级及以上科研获奖
1.“发酵法生产衣康酸技术的研究” 国家科技进步二等奖
2.“海藻糖生产关键技术研发与产业化应用” 山东省技术发明一等奖
3.“典型农林生物质制浆造纸性能提升集成技术及产业化” 山东省科技进步一等奖
4.“饲粮必需氨基酸高产菌株构建关键技术研发与产业化” 山东省科技进步一等奖
5.“发酵法生产衣康酸技术的研究”山东省科技进步一等奖“
6.“功能性低聚糖制造关键酶制剂”天津市科技进步一等奖
7.“淀粉质原料固定化细胞高效转化海藻糖技术产业化” 山东省科技进步二等奖“
8.“畜禽肠道健康合生元制品创新技术及产业化”，山东省科技进步二等奖
9.“饲用酶制剂核心产品的创制、关键技术集成与应用”山东省科技进步三等奖
10.“循环农业系统中废弃物综合利用关键技术集成及应用”，山东省科技进步奖，三等奖
11.“L-赖氨酸高效生产关键技术研发与产业化”中国轻工业联合会科技进步一等奖
12“新型半纤维素酶创制关键技术的开发与应用”，中国轻工业联合会科技进步二等奖
13.“农牧业废弃物制备生物天然气创新技术及产业化”，山东省高等学校科学技术一等奖
14.“吩嗪类生物活性物质的发酵生产及应用”山东省轻工业联合会科技进步一等奖
4.2 省部级及以上科研项目
1.“理性设计低共熔溶剂高效解构木质素及其机制研究”， 国家自然科学基金，2025, 主持
2.“饲用氨基酸先进生产工艺研发和重要品种应用示范”，国家重点研发计划课题，2023年，主持
3.“高适配底盘细胞基因编辑工具的创建”，国家重点研发计划子课题，2023，主持
4. “Fe(Ⅱ)/α-KG依赖型双加氧酶催化合成4-羟基异亮氨酸的构效关系分子机制研究及其功能调控”，国家自然科学基金，2022，主持；
5.“产丁醇梭菌属微生物木糖与葡萄糖同步利用调控机制研究”，国家自然科学基金，2016，主持
6.“氨基葡萄糖生物生产技术"，国家863子课题"，2015，主持
7.“城镇化分散原料集中供气模式研究与应用示范”，国家科技支撑计划课题子课题,2015，主持
8. “果蔬加工废弃物转化生物天然气关键技术及装备”，国家科技支撑计划课题， 2014，主持
9.“新疆维吾尔自治区牛羊肉及乳制品质量安全保障与风险评估技术研究与示范” 山东省技术创新引导计划（中央引导地方科技发展资金）项目， 2024, 主持
10. “沿黄区域宜种粮经作物节水增产关键技术创新与示范”， 山东省重点研发计划项目，2023，主持
11. “高端生物装备制造技术及成套系统”，山东省重点研发计划（重大科技创新工程））2022，主持
12.“新型异亮氨酸-4-羟化酶的立体选择性机制及其分子改造研究”，山东省自然科学基金，2022，主持
13.“可降解PET塑料的模拟酶设计及催化活性研究”，山东省自然科学基金，2022，主持
14. “新型霉菌毒素降解酶的研发与应用”，山东省重点研发计划课题， 2022年，主持
15. “城乡混合有机垃圾定向腐殖化及资源化利用技术”，山东省自然基金重点项目，2021 主持
16. “假单胞菌中2-羟基吩嗪高效合成的分子机制研究”，山东省自然基金，2019，主持
17. “洗涤用酶制剂产品研制的关键技术”，山东省重大专项课题，2019年，负责人
18. “微生物和酶制剂处理造纸白水关键技术集成与应用示范”，山东省重大专项课题， 2018年，主持
19. “新型替抗饲用腐植酸钠制品创新技术及产业化”，山东省农业重大应用技术创新项目， 2018，主持
20. “木素磺酸盐性质、存在状态及其对不同来源纤维素酶影响机制的研究”，山东省自然科学基金，2017，主持
21.“城镇化分散原料厌氧消化及集中供气技术研究山东省重点研发计划”，2017，主持
22. “木质纤维素转化燃料乙醇新工艺的开发与中试放大”，山东省重点研发项目，2016，主持
23. “木质纤维素水解液厌氧消化制备生物燃气关键技术研究山东省博士后创新项目”，2016 主持
24. “高浓底物酶水解提高生物酒精经济竞争力的基础问题研究”，山东省自然基金，2015，主持
25.“果蔬废弃物厌氧消化制备生物燃气关键技术研究”，山东省科技发展计划项目，2014，主持
26.“丙酮丁醇梭菌PTS系统对其木糖代谢的扰动规律及其机理研究”，山东省自然基金，2012，主持.
4.3 授权发明专利
1. 李丕武, 等. 一种酶法制备可降解秸秆地膜的方法: 中国, ZL 202111662854.2
2. 李丕武, 等. 一种生物酶处理的生物机械浆制备方法: 中国, ZL 202210616865.5
3. 李丕武, 等. 一种双包埋生物酶缓释破胶剂及其制备方法: 中国, ZL 202011497431.5
4. 李丕武, 等. 一种通过yoaD和yoaE基因共缺失提高大肠杆菌GlmS酶活力的方法: 中国, ZL 201911365782.8
5. 李丕武, 等. 一种以马铃薯为原料酶法制备葡萄糖酸铵的方法: 中国, ZL 201810980878.4
6. 李丕武, 等. 一株降解小麦戊聚糖的枯草芽孢杆菌MXT-1及其应用: 中国, ZL 201701114507.5
7. 李丕武, 等. 一株产氨基葡萄糖枯草芽孢杆菌的构建方法与应用: 中国, ZL 201610912145.8
8. 李丕武, 等. 从异麦芽酮糖母液中分离异麦芽酮糖和海藻酮糖的方法: 中国, ZL 201410284332.7
9. 李丕武, 等. 一种含有复合益生素的饲料添加剂及其制备方法: 中国, ZL 201110435455.2
10. 刘同军, 等. 一种高浓度植物纤维素浆料固液分离的方法: 中国, ZL 201510459227.7
11. 张杰, 等. 菌株ZW081、组合物及其制备方法与应用: 中国, ZL 202510254002.1
12. 张杰, 等. 具有降尿酸活性的益生菌、复合益生菌剂及其应用:中国, ZL 202410991998.X
13. 张杰, 等. 协同促进肠道益生菌增殖与定植的添加剂及使用方法: 中国, ZL 201710103735.
14. 张杰, 等. 利用拜氏梭菌制备高酯键腐植酸制剂的方法及应用: 中国, ZL 201811473511.X.
15. 张杰, 等. 利用腐植酸钠促进灵菌红素合成与分泌的方法: 中国, ZL 202011028310.6
16. 张杰, 等. 改性腐植酸钠和制备方法及应用: 中国, ZL 202010842956.1
17. 张杰, 等. 一株同步利用葡萄糖与木糖生产醇类燃料的菌株及其应用: 中国, ZL 201510021602.X
18. 张杰, 等. 杂合甘油酯及生产方法和应用:中国, ZL 201710112022.0
19. 张杰, 等. 含低聚糖腐植酸钠制品及其制备和应用: 中国, ZL 201510674736.1
20. 张杰, 等. 以木质纤维素原料联产生物柴油与生物丁醇的方法: 中国, ZL 201210197741.4.
21. 刘开泉, 等. 绿针假单胞菌QOHPHZ-3作为1-羟基-吩嗪生产工程菌株的应用: 中国, ZL 202011023788.X
22. 刘开泉, 等. 一株高产吩嗪-1-羧酸的基因工程菌株及其构建方法和应用: 中国, ZL 202011026544.7
23. 刘开泉, 等. 一种生产1-羟基吩嗪的绿针假单胞菌QOHPHZ-8及应用: 中国, ZL 202011024003.0
24. 刘开泉, 等. 一种用于生产2-羟基-吩嗪的工程菌株及应用: 中国, ZL 202011026637.X
25. 刘开泉, 等. 一株高产吩嗪-1-甲酰胺的基因工程菌株及其构建方法和应用: 中国, ZL 202011024026.1.
26. 刘开泉, 等. 用于生产吩嗪-1-甲酰胺的基因工程菌及其制备方法和用途: 中国, ZL 202011024021.9.
27. 刘开泉, 等. 一种生产2-羟基吩嗪的绿针假单胞菌及制备方法与应用: 中国, ZL 202210461035.X.
28. 刘开泉, 等. 一种高产吩嗪-1-羧酸的绿针假单胞菌基因工程菌及其构建方法和应用: 中国, ZL 202210712676.8.
29. 刘开泉, 等. 一种利用复合菌剂协同酶制剂进行小麦秸秆制浆的方法及产品: 中国, ZL 202211335012.0.
30. 刘开泉, 等. 一种KOH协同生物酶制剂的小麦秸秆制浆方法及产品: 中国, ZL 202211383011.3
31. 刘开泉, 等. 一种以可溶性固形物含量为参数的制浆过程动力学模型: 中国, ZL 2023113910818.
32. 刘开泉, 等. 一种以还原糖含量为参数的制浆过程动力学模型: 中国, ZL 2023113910860.
33. 刘开泉, 等. 一种基于多因素的麦草制浆打浆度拟合方程: 中国, ZL 2023113910733
34. 李霞, 等. 一种纳米纤维肽、纳米纤维肽-氧化石墨烯复合模拟酶及其应用: 中国, ZL 202410826186.X
35. 李霞, 等. 一种多肽模拟酶及其在黄曲霉毒素B1降解上的应用: 中国, ZL 202410825000.9.
36. 李霞, 等.一种多肽模拟酶、固定化模拟酶及其在AFB1降解上的应用，中国, ZL 2024 1 1658078.2
37. 李霞, 等.一种仿生酶及其在降解黄曲霉毒素上的应用，中国, ZL 2025 1 1535093.2
38. 孙登岳等; 一种α/β水解酶在聚乙烯降解中的应用,中国, ZL202411689608.X
39.孙登岳等; 一种 4-羟基异亮氨酸羟化酶突变体、突变基因及其应用,中国, ZL2024109478879
40.孙登岳等; 一种 4-羟基异亮氨酸羟化酶及其编码基因与应用, 中国, ZL 2024109478794
4.4 发表论文
1. Yingying Zheng, Hongwei Liu, Shumin Guo, Jingwen Fei, Junqing Wang, Ruiming Wang, Piwu Li*. (2026) An adsorption-crosslinking immobilization approach for enhancing the operational stability of D-allulose 3-epimerase immobilized on chitosan-modified resin. Biochemical Engineering Journal 227, 110039.
2. Ruida Shan, Yishu Wang, Shuxin Cheng, Xia Li, Xiaohui Yang, Dengyue Sun, and Piwu Li*. (2025) Biochemical and structural characterization of a novel L-isoleucine-4-dioxygenase(RaIDO) from Rahnella aquatilis. Protein Expression and Purification 226, 106604.
3. Keyi Liu, Junqing Wang, Feng Li, Ruiming Wang, Qingming Zeng, Zhenxing Zhang, Hongwei Liuand Piwu Li*. (2024) Proline Improves Pullulan Biosynthesis Under High Sugar Stress Condition. Microorganisms 12, 2657.
4. Piwu Li*, Jierui Gu, Keyi Li, and Qingming Zeng. (2024) The impacts of pullulan soaking on radish seed germination and seedling growth under salt stress. Bioscience Biotechnology and Biochemistry 88(8), 923-931.
5. Xia Li, YaolingZhou, Zirui Lu, Ruida Shan, Dengyue Sun, JianpengLi, and Piwu Li*. (2023) Switchable enz y me mimics based on self-assembled p e p tides for p ol y eth y lene tere p hthalate de g radation. Journal of Colloid and Interface Science 646, 198-208.
6. Piwu Li, Xiaofen g Wei, Yun Wan g, Hui Liu, Yan p en g Xu, Zi y an g Zhan g, Junlin Li, Jianbin Wan g, Chuanzhuan g Guo, Son g sen Sui, Jun q in g Wan g*, and RuimingWang. (2023) Im provement of optimumpH and specific activityofpectate l yase from Bacillus RN.1usingloopreplacement. Frontiers in Bioen g ineerin g and Biotechnolo gy 4:11, 1242123.
7. PiwuLi,Yan p en g Xu, Lian g Yin,Xiaoli Lian g, Ruimin g Wan g,and Kai q uan Liu*. (2023) Develop ment of Raw Materials and Technology for Pul p in g-A Brief Review. Pol y mers 15(22), 4465.
8. PiwuLi, Fei Zhao,Xiaofen g Wei,Xian g lin g Tao,and Fen g Din g^. (2022) Biolo g ical modificationof p entosans in wheat B starch wastewaterand p re p arationof a com positefilm. BMCBiotechnology 22(1), 4.
9. Piwu Li, Jun Ma, Xiaofeng Wei, Ziyang Zhang, Ruiming Wang, Jing Xiao and Junqing Wang*. (2022) Modification and application of highly active alkaline pectin lyase. AMB EXPRESS 12(1), 1-10.
10. Zhiwei Zhang, Fei Zhao, Yuling Meng, Junzhang Lin, Yanpeng Xu, Yun Feng, Feng Ding, andPiwu Li*. (2022) Microencapsulation of the Enzyme Breaker by Double-Layer Embedding Method. SPE Journal 28(02), 908-916.
11. Yuling Meng, Fei Zhao, Xianwei Jin, Yun Feng, Gangzheng Sun, Junzhang Lin, Baolei Jia, and Piwu Li*. (2021) Performance Evaluation of Enzyme Breaker for Fracturing Ap-plications Under Simulated Reservoir Conditions. Molecules 11, 3133.
12. Piwu Li, Bingcui Chen, Feng Ding*. (2020) Gluconate enhanced the water uptake and improved the growth of rice seedlings under PEG-induced osmotic stress. Plant Physiology and Biochemistry 156(1), 514-525.
13. Piwu Li, Xu Li, Zhao Wen, Ruizhen Dong, Kang Li, Han Fan, Ruiming Wang, and Junqing Wang*. (2020) Enhancement of Production of d Glucosamine in Escherichia coli by Blocking Three Pathways Involved in the Consumption of GlcN and GlcNAc. Molecular Biotechnology 62, 387–399.
14. Piwu Li. KangLi. X Li. Fei Zhao. Ruimin gWang, and Junqin gWang*. (2020) Improvingenzyme activityofglucosamine-6-phosphate synthase by semi-rational design strategyand computer analysis. Biotechnol Lett 42, 2319–2332.
15. Bin gcui Chen, Kang Li, Lin gtongLiao, RuimingWang, and Piwu Li*. (2019) Ammonium Gluconate Production from Potato Starch Wastewater Using Multi-Enzyme Process. American Journal of Potato Research 96(5), 447-456.
16. Lin gtongLiao, YulingMeng, RuimingWang, Baolei Jia and Piwu Li*. (2019) Cou p lin g and Re g ulation of Porous Carriers Usin g Plasma and Amination to Im p rove the Catal y tic Performance of Glucose Oxidase and Catalase. Frontiersin Bioen g ineerin g and Biotechnolo gy 7, 426.
17. Wan gShen g. Li Piwu*,Su Jin g,WuXian g kun,and Lian g Ron g ron g. (2014) Characterizationand ex p ressionof g lucosamine-6-p hos p hate s y nthase fromSaccharom y ces cerevisiaein Pichia p astoris. Biotechnolo gy Letters 36(10), 2023-8.
18. Wang Sheng. Li Piwu*, Su Jing, Liang Rongrong, and Wu Xiangkun. (2014) Glucosamine Production with Actinomucor elegans Based on Stimulating Factor of Methanol. Indian Journal of Microbiology 54(4), 459-465.
19.L Tan, Z Liu, T Zhang, Z Wang, T Liu*. (2020) Enhanced enzymatic digestibility of poplar wood by quick hydrothermal treatment. Bioresource Technology, 122795.
20. L Tan, Z Liu, T Liu*, T Wang. (2020) Changes of the Structures and Properties of Corn Stover during Acid Sulfite Pretreatment for Improved Enzymatic Hydrolysis. BioResources 15(1), 1001-1013.
21. T Liu, L Yang, B Liu, L Tan. (2019) Hydroxycinnamic acids release during bioconversion of corn stover and their effects on lignocellulolytic enzymes. Bioresource technology 294, 122116.
22. X Liu, P Hille, M Zheng, P Gao, K Shang, R Wei, T Liu*, L Qu. (2019) Diversity of polyester degrading bacteria in surface sediments from Yangtze River Estuary. AIP Conference Proceedings 2122(1), 020063.
23. L Tan, Z Liu, T Liu*, F Wang. (2019) Efficient fractionation of corn stover by bisulfitepretreatment for the production of bioethanol and hi gh value products. BioResources 14(3), 6501-6515.
24. B Liu, Z Lian, Z Liu, R Zhao, L Yang, X Zhang, L Tan, T Liu*. (2019) Studyon saccharification and alcohol fermentation of alkalinepretreated corn cob. AIP Conference Proceedin gs 2110(1), 020024.
25. B Tian, T Liu*. (2019) Comprehensive utilization research status of Jerusalem artichoke. AIP Conference Proceedin gs 2110(1), 020019.
26. JDC, ML, DLW, ADS, TL, DB Hodge. (2019) Alkaline and Alkaline-Oxidative Pretreatment and Hydrolysis of Herbaceous Biomass for Growth of Oleaginous Microbes. Microbial Li p id Production. Methods in Molecular Biolo gy, vol 1995. Humana.
27. T Liu*, Z Li. (2017) An electrogenerated base for the alkaline oxidative pretreatment of lignocellulosic biomass to produce bioethanol. RSC advances 7(75), 47456-47463.
28. KJ Tomek, CRC Saldarriaga, FPC Velasquez, T Liu*, DB Hodge. (2015) Removal and upgrading of lignocellulosic fermentation inhibitors by in situ biocatalysis and liquid-liquid extraction. Biotechnology and bioengineering 112(3), 627-632.
29. Tongjun Liu, Daniel L Williams, Muyang Li, Sivakumar, DBH. (2014) Coupling alkaline pre-extraction with alkaline-oxidative post-treatment of corn stover to enhance enzymatic hydrolysis and fermentability. Biotechnology for Biofuels 7, 48.
30. TK Sato, T Liu, LS Parreiras, DL Williams, DJ Wohlbach, BD Bice, IM Ong, et al. (2014) Harnessing genetic diversity in Saccharomyces cerevisiae for fermentation of xylose in hydrolysates of alkaline hydrogen peroxide-pretreated biomass. Appl. Environ. Microbiol. 80(2), 540-554.
31. LS Parreiras, RJ Breuer, RA Narasimhan, AJ Hi gbee, A La Reau. (2014) En g ineerin g and two-sta g e evolution of a li g nocellulosic h y drol y sate-tolerant Saccharom y ces cerevisiae strain for anaerobic fermentation of x y lose from AFEX pretreated corn stover. PloS one 9(9), 70.
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