|
1.工业微生物的代谢途径改造及表达体系构建 2.生物基平台化合物的生物法制备 3.工业酶制剂的改造与高效表达 4.生物质资源的高值化利用 |
|
1.中国生物工程学会会员 2.中国微生物学会会员 |
|
纵向课题 1.国家自然科学基金青年基金,22308180,全细胞催化合成2,5-呋喃二甲酸的关键酶及底物转运机制研究,2024.01-2026.12,30万元,主持; 2.山东省自然科学基金青年基金,ZR2020QB041,5-羟甲基糠醛氧化还原酶HmfH的催化机制及其制备2,5-呋喃二甲酸的研究,2021.01-2023.12,15万元,主持; 3.齐鲁工业大学生物及生物化学ESI学科开放课题,No.202018,5-羟甲基糠醛氧化还原酶催化制备2,5-呋喃二甲酸的机制研究,2020.09-2022.08,10万元,主持; 4.生物基材料与绿色造纸国家重点实验室自主研究课题,ZZ20190314,2,5-呋喃二甲酸的单酶法制备研究,2019.12-2021.12,5万元,主持; 5.国家自然科学基金青年基金,31600068,代谢工程改造枯草芽孢杆菌合成N-乙酰神经氨酸关键问题的研究,2017.01-2019.12,21万元,参与; 6.山东省重点研发计划(重大科技创新工程),2022CXGC010506,一步混菌发酵制备维生素C,2022.02-2025.02,1000万元,参与。 技术研发 1. 酶法制备熊去氧胆酸关键工艺技术开发,企业技术研发,37 元,主持 |
|
期刊论文 1.Xiangling Jiang, Changtong Chen, Mingxia Jiao, Jianqi He, Xuechun Han, Tengfei Wang, Di Huang, Yi Jiang, Hongling Liu, Haibo Yuan. Whole-Cell Biocatalytic Production of 2,5-Furandicarboxylic Acid from 5-Hydroxymethylfurfural by Bacillus subtilis J8M8[J]. Microorganisms, 2026, 14(2):425. 2.Tengfei Wang, Haodong Sun, Han Xue, Changtong Chen, Di Huang, Yi Jiang, Hongling Liu, Haibo Yuan. Production of trehalose using reusable cellulose microsphere immobilized enzymes via SpyTag and SpyCatcher [J]. Molecular Catalysis, 2025, 574: 114894. 3.Wenhu Chen#, Qian Liu#, Meng Liu, Hongling Liu, Di Huang, Yi Jiang, Tengfei Wang, Haibo Yuan. Symbiosis mechanism of associated bacteria on 2-keto-L-gulonic acid production via mixed fermentation: A Review[J]. Fermentation, 2023, 9(12):1000. 4.Haibo Yuan, Jianghua Li, Hyun-dong Shin, Guocheng Du, Jian Chen, Zhongping Shi, Long Liu. Improved production of 2,5-furandicarboxylic acid by overexpression of 5-hydroxymethylfurfural oxidase and 5-hydroxymethylfurfural/furfural oxidoreductase in Raoultella ornithinolytica BF60[J]. Bioresource Technology, 2018, 247: 1184-1188. 5.Haibo Yuan, Yanfeng Liu, Jianghua Li, Hyun-dong Shin, Guocheng Du, Zhongping Shi, Jian Chen, Long Liu. Combinatorial synthetic pathway fine-tuning and comparative transcriptomics for metabolic engineering of Raoultella ornithinolytica BF60 to efficiently synthesize 2,5-furandicarboxylic acid[J]. Biotechnology and Bioengineering, 2018, 115(9): 2148-2155. 6.Haibo Yuan, Hongling Liu, Jieke Du, Kaiquan Liu, Tengfei Wang, Long Liu. Biocatalytic production of 2,5-furandicarboxylic acid: recent advances and future perspectives[J]. Applied Microbiology and Biotechnology, 2020, 104(2): 527-543. 7.Haibo Yuan, Yanfeng Liu, Xueqin Lv, Jianghua Li, Guocheng Du, Zhongping Shi, Long Liu. Enhanced 2,5-furandicarboxylic acid (FDCA) production in Raoultella ornithinolytica BF60 by manipulation of the key genes in FDCA biosynthesis pathway[J]. Journal of Microbiology and Biotechnology, 2018, 28(12): 1999-2008. 8.Zekun Tao#, Haibo Yuan#, Meng Liu, Qian Liu, Siyi Zhang, Hongling Liu, Yi Jiang, Di Huang, Tengfei Wang. Yeast Extract: Characteristics, Production, Applications and Future Perspectives[J]. Journal of Microbiology and Biotechnology, 2023, 33(2):151-166. 9.Hanyu Cong#, Haibo Yuan#, Zekun Tao, Hanlin Bao, Zheming Zhang, Yi Jiang, Di Huang, Hongling Liu, Tengfei Wang. Recent Advances in Catalytic Conversion of Biomass to 2,5-Furandicarboxylic Acid[J]. Catalysts, 2021, 11, 1113. 10.Ping Lin#, Haibo Yuan#, Jieke Du, Kaiquan Liu, Hongling Liu, Tengfei Wang. Progress in research and application development of surface display technology using Bacillus subtilis spores[J]. Applied Microbiology and Biotechnology, 2020, 104(6):2319-2331. |
|
本科生课程 1.《生物工程设备》(32学时) 2.《分子生物学与基因工程》(48学时) 3.《生物工程设备课程设计》(两周) 4.《认识实习》(1周) 研究生课程 1.《发酵过程优化与控制》(32学时) 2.《基因工程》(32学时) 3.《现代工业发酵调控学》(32学时) 4.《食品生物工程》(32学时) |
|
1. 第九届山东省“互联网+”大学生创新创业大赛,金奖,指导教师(1/3) 2. 第九届全国大学生生命科学竞赛(创新创业类),一等奖,指导教师(2/2) 3. 第九届全国大学生生命科学竞赛(科学探究类)山东赛区,二等奖,指导教师(2/2) 4. 第八届中国国际“互联网+”大学生创新创业大赛,银奖,指导教师(7/8) 5. 第十八届“挑战杯”山东省大学生课外学术科技作品竞赛“黑科技”展示活动,二等奖,指导教师(2/3) |



